Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens.
نویسندگان
چکیده
In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 40 شماره
صفحات -
تاریخ انتشار 2015